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Trapped Neutrophil Syndrome     TNS Test   Code 370

Test Pricing

For breeds: Border Collie

Trapped Neutrophil Syndrome (TNS) is an inherited disease that affects a dog's immune system and is marked by an inability to effectively combat infections. Clinical symptoms of dogs affected by TNS vary, depending on the nature of the pathogen involved. Australian researchers, Jeremy Shearman and Dr. Alan Wilton, have identified and characterized the mutation causing  TNS in the Border Collie.

The TNS mutation is widely distributed, occurring in over 10% of the population of both working and show lines of Border Collies.  Dr. Wilton has worked closely with OptiGen, providing technical assistance and has endorsed OptiGen's offering of the TNS test that he and his research team have developed. We are pleased that OptiGen is now able to offer DNA testing at our laboratory in Ithaca, NY. If you would like to have a TNS test run on a sample from a Border Collie that you have previously tested through OptiGen, it is very likely that the DNA will still be archived from the original submission. Simply indicate on the order form that the sample is already at OptiGen. 

Breeding recommendations: TNS is inherited in a simple autosomal recessive manner. Carriers do not show symptoms of the disease. The table below shows the expected results from breeding dogs of each genetic status. It is important never to breed two carrier dogs, because on average, 25% of the pups could be affected. At least one parent should always be clear/normal for the disease.

References: Shearman JR, Wilton AN. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. BMC Genomics. 2011. V. 12:258.

 

 
Expected results for breeding strategies using the
OptiGen mutation test for Trapped Neutrophil Syndrome (TNS)
Parent 1
Genotype
Parent 2 Genotype
Normal/ClearCarrierAffected
Normal/ClearAll = Normal/Clear1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected All = Carrier
1/2 = Carrier
1/2 = Affected

All = Affected


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